Scarlet Fever and IGAS

1 Background

Group A Streptococcus (GAS) are common bacteria. GAS can be present on or in the human body, without causing infection (colonisation), but may cause skin, soft tissue and respiratory infections, including scarlet fever. GAS infections range from mild to very severe. Invasive GAS (IGAS) occurs when the bacteria proliferate in a normally sterile body site, such as the blood, soft tissues or joints. Streptococcal toxic shock syndrome (STSS) can be a severe complication of IGAS, caused by toxins that are produced by GAS, which act on host cells or tissues.

GAS is spread by close contact between individuals, through respiratory droplets and direct skin contact. GAS can also be transmitted indirectly through contact with inanimate objects, such as towels or bedding. GAS is usually diagnosed by microbiological culture of a specimen from the affected site or by a characteristic illness, such as scarlet fever.

The reduced number of cases in 2020 and 2021 during the COVID-19 pandemic is likely in part due to reduced social contact and increased use of preventive measures, and therefore lower transmission during that period. The reduction might also partly reflect changes in healthcare seeking or access during that period.

Public and clinician awareness of GAS infections has changed over time, especially during December 2022, which may contribute to changes in trends. IGAS, being more severe, is likely more consistent over time.

Detail of case definitions and methods are at the end of this document. Data were correct at 9am on 24 April 2024.

2 Cumulative number of scarlet fever and IGAS cases, 2022-2024.

The number of cases from the start of 2022 until the report date are shown (Table 2.1).

Table 2.1: Counts of cases of IGAS and scarlet fever, 2022-2024.
  IGAS Scarlet Fever
  (N=211) (N=2947)
Infection    
Confirmed 194 (91.9%) 215 (7.30%)
Probable 17 (8.06%) 2732 (92.7%)

3 Scarlet Fever

4 Invasive Group A Streptococcal Infection

5 Discussion

There was an increase in scarlet fever incidence during January 2023, this increase was also observed in other European nations. There has been an increase in the number of IGAS infections compared to the pandemic period. While IGAS incidence has steadily fallen since December 2022 and January 2023, the monthly incidence remains at levels in keeping with previous moderate seasons.

5.1 Four Nations Rapid Review of IGAS

On 4th March 2024 a rapid review into IGAS deaths in children that occurred at the end of 2022 and early 2023 was published in collaboration with PHA, Public Health Wales (PHW), UK Health Security Agency (UKHSA), Public Health Scotland and the National Child Mortality database. This review, Four Nations Rapid Review of iGAS Deaths in Children can be accessed by visiting https://phw.nhs.wales/fournationsigasreport.

6 Methods

Scarlet fever notifications and IGAS cases are reported by clinicians to the Public Health Agency and were extracted from the case management database. Laboratory reports of IGAS are also reported and validated with those reported by clinicians. Scarlet fever is notifiable in Northern Ireland under the Public Health Act (1967) Northern Ireland and IGAS is not notifiable.

Cases are presented by the date that they were recorded on the PHA database. Notified cases will be removed from future reports if PHA is notified that clinical investigations later result in an alternative diagnosis. Numbers may therefore reduce.

Data were processed in R.

6.1 Scarlet Fever Case Definitions

Confirmed case: Clinical diagnosis of scarlet fever by a health professional and GAS detected on a throat swab

Probable case: Clinical diagnosis of scarlet fever by a health professional

6.2 IGAS Case Definitions

Confirmed case: An individual who has an IGAS infection, which is defined as the isolation of group A Streptococcus (GAS) from a normally sterile body site, such as blood, cerebrospinal fluid, joint aspirate, pericardial/peritoneal/pleural fluids, bone, endometrium, deep tissue or deep abscess at operation or post-mortem. It also includes severe GAS infections, where GAS has been isolated from a normally non-sterile site such as throat, sputum, vagina or wound in combination with a severe clinical presentation, such as streptococcal toxic shock syndrome (STSS), necrotising fasciitis, pneumonia, septic arthritis, meningitis, peritonitis, osteomyelitis, myositis or puerperal sepsis, and cellulitis accompanied by a systemic presentation necessitating hospitalisation.

Probable case: An individual who has a severe clinical presentation consistent with IGAS infection, such as STSS, necrotising fasciitis, myositis, puerperal sepsis, and cellulitis accompanied by a systemic presentation necessitating hospitalisation, in the absence of microbiological confirmation of GAS AND either:

  1. the clinician considers that GAS is the most likely cause

  2. there is an epidemiological link to a confirmed case.

7 Supplementary Table

Table 7.1: Counts of probable and confirmed cases of scarlet fever by week, 2022-2024.
Recorded in Week Commencing Count
2022-01-03 0
2022-01-10 0
2022-01-17 0
2022-01-24 2
2022-01-31 1
2022-02-07 1
2022-02-14 1
2022-02-21 1
2022-02-28 0
2022-03-07 12
2022-03-14 2
2022-03-21 1
2022-03-28 6
2022-04-04 2
2022-04-11 5
2022-04-18 2
2022-04-25 2
2022-05-02 5
2022-05-09 4
2022-05-16 2
2022-05-23 6
2022-05-30 4
2022-06-06 4
2022-06-13 4
2022-06-20 2
2022-06-27 3
2022-07-04 5
2022-07-11 2
2022-07-18 4
2022-07-25 2
2022-08-01 1
2022-08-08 3
2022-08-15 2
2022-08-22 4
2022-08-29 1
2022-09-05 6
2022-09-12 2
2022-09-19 4
2022-09-26 5
2022-10-03 3
2022-10-10 7
2022-10-17 3
2022-10-24 12
2022-10-31 7
2022-11-07 23
2022-11-14 11
2022-11-21 13
2022-11-28 43
2022-12-05 183
2022-12-12 192
2022-12-19 220
2022-12-26 124
2023-01-02 265
2023-01-09 258
2023-01-16 365
2023-01-23 80
2023-01-30 83
2023-02-06 68
2023-02-13 47
2023-02-20 28
2023-02-27 45
2023-03-06 54
2023-03-13 17
2023-03-20 37
2023-03-27 34
2023-04-03 35
2023-04-10 19
2023-04-17 13
2023-04-24 5
2023-05-01 7
2023-05-08 10
2023-05-15 13
2023-05-22 17
2023-05-29 9
2023-06-05 17
2023-06-12 12
2023-06-19 1
2023-06-26 3
2023-07-03 7
2023-07-10 0
2023-07-17 4
2023-07-24 5
2023-07-31 2
2023-08-07 4
2023-08-14 3
2023-08-21 2
2023-08-28 0
2023-09-04 2
2023-09-11 1
2023-09-18 4
2023-09-25 3
2023-10-02 5
2023-10-09 11
2023-10-16 3
2023-10-23 7
2023-10-30 6
2023-11-06 9
2023-11-13 11
2023-11-20 14
2023-11-27 10
2023-12-04 20
2023-12-11 10
2023-12-18 11
2023-12-25 10
2024-01-01 36
2024-01-08 11
2024-01-15 11
2024-01-22 17
2024-01-29 23
2024-02-05 26
2024-02-12 18
2024-02-19 11
2024-02-26 22
2024-03-04 15
2024-03-11 21
2024-03-18 28
2024-03-25 16
2024-04-01 10
2024-04-08 14
2024-04-15 4
2024-04-22 4